April 27, 2012 Book section Open Access

Klaus Draenert; Yvette Draenert; Tim Pohlemann; Gerd Regel

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    <subfield code="a">There are two models for studying degradation and lamination of hyaline articular cartilage: the Silberberg mouse (Silberberg et al. 1965a, b) and the ACL-cut model on animals (Draenert and Draenert 1981). The Silberberg mouse develops during the first year of severe varus osteoarthritis in the knee joint. The varus deformation is induced by hormones. The osteoarthritis reveals all signs of a progredient degradation of the joint with the development of osteophytes (Fig. 4.1) and destruction of the hyaline cartilage, which is abraded in layers (Figs. 4.2 and 4.3). Simultaneous with the destruction, reparation processes with newly produced ground substance and proliferating cells can be observed (Fig. 4.4).</subfield>
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