January 12, 2021 Journal article Closed Access

Hadewych Van Hauwermeiren; Jean-Paul Aben; Osama Ibrahim Ibrahim Soliman; Liesbeth Rosseel; Masafumi Ono; Bill Brunnett; Chun Chin Chang; Martijn Cox; Yoshinobu Onuma; Michele Pighi; Darren Mylotte; Rodrigo Modolo; Patrick W. Serruys; Willem Flameng; Rutao Wang; Hideyuki Kawashima; Philippe Pibarot

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{
  "@context": "https://schema.org/", 
  "@id": "https://doi.org/10.1016/j.jcin.2021.04.046", 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Hadewych Van Hauwermeiren"
    }, 
    {
      "@type": "Person", 
      "name": "Jean-Paul Aben"
    }, 
    {
      "@type": "Person", 
      "name": "Osama Ibrahim Ibrahim Soliman"
    }, 
    {
      "@type": "Person", 
      "name": "Liesbeth Rosseel"
    }, 
    {
      "@type": "Person", 
      "name": "Masafumi Ono"
    }, 
    {
      "@type": "Person", 
      "name": "Bill Brunnett"
    }, 
    {
      "@type": "Person", 
      "name": "Chun Chin Chang"
    }, 
    {
      "@type": "Person", 
      "name": "Martijn Cox"
    }, 
    {
      "@type": "Person", 
      "name": "Yoshinobu Onuma"
    }, 
    {
      "@type": "Person", 
      "name": "Michele Pighi"
    }, 
    {
      "@type": "Person", 
      "name": "Darren Mylotte"
    }, 
    {
      "@type": "Person", 
      "name": "Rodrigo Modolo"
    }, 
    {
      "@type": "Person", 
      "name": "Patrick W. Serruys"
    }, 
    {
      "@type": "Person", 
      "name": "Willem Flameng"
    }, 
    {
      "@type": "Person", 
      "name": "Rutao Wang"
    }, 
    {
      "@type": "Person", 
      "name": "Hideyuki Kawashima"
    }, 
    {
      "@type": "Person", 
      "name": "Philippe Pibarot"
    }
  ], 
  "datePublished": "2021-01-12", 
  "description": "This study aimed to validate a dedicated software for quantitative videodensitometric angiographic assessment of mitral regurgitation (QMR).Quantitative videodensitometric aortography of aortic regurgitation using the time-density principle is a well-documented technique, but the angiographic assessment of mitral regurgitation (MR) remains at best semi-quantitative and operator dependent.Fourteen sheep underwent surgical mitral valve replacement using 2 different prostheses. Pre-sacrifice left ventriculograms were used to assess MR fraction (MRF) using QMR and MR volume (MRV). In an independent core lab, the CAAS QMR 0.1 was used for QMR analysis. In\u00a0vitro MRF and MRV were assessed in a mock circulation at a comparable cardiac output to the in\u00a0vivo one by thermodilution. The correlations and agreements of in\u00a0vitro and in\u00a0vivo MRF, MRV, and interobserver reproducibility for QMR analysis were assessed using the averaged cardiac cycles (CCs).In\u00a0vivo derived MRF by QMR strongly correlated with in\u00a0vitro derived MRF, regardless of the number of the CCs analyzed (best correlation: 3 CCs y\u00a0=\u00a00.446\u00a0+ 0.994x; R\u00a0=\u00a00.784; p =0.002). The mean absolute difference between in\u00a0vitro derived MRF and in\u00a0vivo derived MRF from 3 CCs was 0.01 \u00b1 4.2% on Bland-Altman analysis. In\u00a0vitro MRV and in\u00a0vivo MRV from 3 CCs were very strongly correlated (y\u00a0=\u00a00.196\u00a0+ 1.255x; R\u00a0=\u00a00.839; p\u00a0\u00a00.001). The mean absolute difference between in\u00a0vitro MRV and in\u00a0vivo MRV from 3 CCs was -1.4 \u00b1 1.9\u00a0ml. There were very strong correlations of in\u00a0vivo MRF between 2 independent analysts, regardless of the number of the CCs.In\u00a0vivo MRF using the novel software is feasible, accurate, and highly reproducible. These promising\u00a0results have led us to initiate the first human feasibility study comprising patients undergoing percutaneous mitral valve edge-to-edge repair.", 
  "headline": "Validation of Prosthetic Mitral Regurgitation Quantification Using Novel Angiographic Platform by Mock Circulation.", 
  "identifier": "https://doi.org/10.1016/j.jcin.2021.04.046", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "inLanguage": {
    "@type": "Language", 
    "alternateName": "eng", 
    "name": "English"
  }, 
  "keywords": [
    "Netherlands", 
    "Cardiology and Cardiovascular Medicine"
  ], 
  "license": "https://creativecommons.org/licenses/by-nc-nd/4.0/", 
  "name": "Validation of Prosthetic Mitral Regurgitation Quantification Using Novel Angiographic Platform by Mock Circulation.", 
  "url": "https://www.openaccessrepository.it/record/85687"
}