Journal article Open Access
Barak; Paola Ferrari; Angelo Carpi; Andrea Nicolini; Paolo Miccoli; Massimo Conte; Michael J. Duffy; Giorgio Rossi
{ "conceptrecid": "119228", "created": "2023-09-27T08:58:03.484839+00:00", "doi": "10.2741/e348", "files": [ { "bucket": "3dec2d8b-e508-4934-a618-c9917a3fcdee", "checksum": "md5:668e73b56e0c40350341348f7c2fd66b", "key": "fulltext.pdf", "links": { "self": "https://www.openaccessrepository.it/api/files/3dec2d8b-e508-4934-a618-c9917a3fcdee/fulltext.pdf" }, "size": 211518, "type": "pdf" } ], "id": 119229, "links": { "badge": "https://www.openaccessrepository.it/badge/doi/10.2741/e348.svg", "bucket": "https://www.openaccessrepository.it/api/files/3dec2d8b-e508-4934-a618-c9917a3fcdee", "doi": "https://doi.org/10.2741/e348", "html": "https://www.openaccessrepository.it/record/119229", "latest": "https://www.openaccessrepository.it/api/records/119229", "latest_html": "https://www.openaccessrepository.it/record/119229" }, "metadata": { "access_right": "open", "access_right_category": "success", "communities": [ { "id": "itmirror" } ], "creators": [ { "name": "Barak" }, { "name": "Paola Ferrari" }, { "name": "Angelo Carpi" }, { "name": "Andrea Nicolini" }, { "name": "Paolo Miccoli" }, { "name": "Massimo Conte" }, { "name": "Michael J. Duffy" }, { "name": "Giorgio Rossi" } ], "description": "Metastatic colorectal and other locally advanced gastrointestinal (G.I.) cancers often recur after curative resection. Many mechanisms of tumor growth and/or immune escape by residual cancer cells may provoke tumor progression. Long-term, cytostatic action with repeated post-adjuvant administration of 5-fluorouracil (FU)-leucovorin (LV) cycles may interrupt or downregulate these mechanisms and favor the recovery and/or increase the immune system activity. Seventy patients were considered. An active prospective cohort including 21 patients (study group) was matched in a 1:1 ratio with a retrospective parallel control group of 21 patients. The study group received long-term repeated post-adjuvant administration of 5-FU-LV cycles, while the matched control group was conventionally treated. Statistical analysis was performed by Kaplan-Meier method and Cox's proportional hazard regression model. The five-year disease-free survival (DFS) was 77.0 + 10.1 % and 31.7 + 10.6 % (p = 0.001; hazard ratio (HR) 5.3, 95 % C.I.: 1.7-16.1, p = 0.003), while the five-year overall survival (OS) was 88.0 + 8.1 % and 37.0 + 10.7 % (p = 0.001; HR 8.9, 95 % C.I.: 2.0-39.9, p = 0.004) in the study group and in matched controls respectively. These findings suggest a relevant improvement in the outcome of this population by an intermittent and prolonged cytostatic effect with 5-FU-LV.", "doi": "10.2741/e348", "keywords": [ "General Immunology and Microbiology", "General Biochemistry, Genetics and Molecular Biology" ], "language": "eng", "license": { "id": "other-open" }, "notes": "", "publication_date": "2011-01-01", "relations": { "version": [ { "count": 1, "index": 0, "is_last": true, "last_child": { "pid_type": "recid", "pid_value": "119229" }, "parent": { "pid_type": "recid", "pid_value": "119228" } } ] }, "resource_type": { "subtype": "article", "title": "Journal article", "type": "publication" }, "title": "Additional 5-FU-LV significantly increases survival in gastrointestinal cancer." }, "owners": [ 14 ], "revision": 1, "stats": { "downloads": 0.0, "unique_downloads": 0.0, "unique_views": 0.0, "version_downloads": 0.0, "version_unique_downloads": 0.0, "version_unique_views": 0.0, "version_views": 0.0, "version_volume": 0.0, "views": 0.0, "volume": 0.0 }, "updated": "2023-09-27T08:58:03.614954+00:00" }
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