Journal article Open Access
Barak; Paola Ferrari; Angelo Carpi; Andrea Nicolini; Paolo Miccoli; Massimo Conte; Michael J. Duffy; Giorgio Rossi
<?xml version='1.0' encoding='UTF-8'?> <record xmlns="http://www.loc.gov/MARC21/slim"> <leader>00000nam##2200000uu#4500</leader> <datafield tag="540" ind1=" " ind2=" "> <subfield code="a">Other (Open)</subfield> </datafield> <datafield tag="542" ind1=" " ind2=" "> <subfield code="l">open</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">publication</subfield> <subfield code="b">article</subfield> </datafield> <controlfield tag="001">119229</controlfield> <datafield tag="520" ind1=" " ind2=" "> <subfield code="a">Metastatic colorectal and other locally advanced gastrointestinal (G.I.) cancers often recur after curative resection. Many mechanisms of tumor growth and/or immune escape by residual cancer cells may provoke tumor progression. Long-term, cytostatic action with repeated post-adjuvant administration of 5-fluorouracil (FU)-leucovorin (LV) cycles may interrupt or downregulate these mechanisms and favor the recovery and/or increase the immune system activity. Seventy patients were considered. An active prospective cohort including 21 patients (study group) was matched in a 1:1 ratio with a retrospective parallel control group of 21 patients. The study group received long-term repeated post-adjuvant administration of 5-FU-LV cycles, while the matched control group was conventionally treated. Statistical analysis was performed by Kaplan-Meier method and Cox's proportional hazard regression model. The five-year disease-free survival (DFS) was 77.0 + 10.1 % and 31.7 + 10.6 % (p = 0.001; hazard ratio (HR) 5.3, 95 % C.I.: 1.7-16.1, p = 0.003), while the five-year overall survival (OS) was 88.0 + 8.1 % and 37.0 + 10.7 % (p = 0.001; HR 8.9, 95 % C.I.: 2.0-39.9, p = 0.004) in the study group and in matched controls respectively. These findings suggest a relevant improvement in the outcome of this population by an intermittent and prolonged cytostatic effect with 5-FU-LV.</subfield> </datafield> <datafield tag="245" ind1=" " ind2=" "> <subfield code="a">Additional 5-FU-LV significantly increases survival in gastrointestinal cancer.</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-itmirror</subfield> </datafield> <datafield tag="650" ind1="1" ind2="7"> <subfield code="a">cc-by</subfield> <subfield code="2">opendefinition.org</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Paola Ferrari</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Angelo Carpi</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Andrea Nicolini</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Paolo Miccoli</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Massimo Conte</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Michael J. Duffy</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Giorgio Rossi</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">General Immunology and Microbiology</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">General Biochemistry, Genetics and Molecular Biology</subfield> </datafield> <controlfield tag="005">20230927085803.0</controlfield> <datafield tag="024" ind1=" " ind2=" "> <subfield code="a">10.2741/e348</subfield> <subfield code="2">doi</subfield> </datafield> <datafield tag="100" ind1=" " ind2=" "> <subfield code="a">Barak</subfield> </datafield> <datafield tag="856" ind1="4" ind2=" "> <subfield code="s">211518</subfield> <subfield code="u">https://www.openaccessrepository.it/record/119229/files/fulltext.pdf</subfield> <subfield code="z">md5:668e73b56e0c40350341348f7c2fd66b</subfield> </datafield> <datafield tag="041" ind1=" " ind2=" "> <subfield code="a">eng</subfield> </datafield> <datafield tag="260" ind1=" " ind2=" "> <subfield code="c">2011-01-01</subfield> </datafield> </record>
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