Journal article Closed Access
Monica Terracciano; Chiara Tramontano; Chiara Tramontano; Gianluigi Zito; Stefano Managò; Luca De Stefano; Enza Lonardo; Donatella Delle Cave; Ilaria Rea; Giovanna Chianese; Anna Chiara De Luca
{ "@context": "https://schema.org/", "@id": "https://doi.org/10.1002/smll.202101711", "@type": "ScholarlyArticle", "creator": [ { "@type": "Person", "name": "Monica Terracciano" }, { "@type": "Person", "name": "Chiara Tramontano" }, { "@type": "Person", "name": "Chiara Tramontano" }, { "@type": "Person", "name": "Gianluigi Zito" }, { "@type": "Person", "name": "Stefano Manag\u00f2" }, { "@type": "Person", "name": "Luca De Stefano" }, { "@type": "Person", "name": "Enza Lonardo" }, { "@type": "Person", "name": "Donatella Delle Cave" }, { "@type": "Person", "name": "Ilaria Rea" }, { "@type": "Person", "name": "Giovanna Chianese" }, { "@type": "Person", "name": "Anna Chiara De Luca" } ], "datePublished": "2021-07-24", "description": "AbstractThe small molecule Galunisertib (LY2157299, LY) shows multiple anticancer activities blocking the transforming growth factor\u2010\u03b21 receptor, responsible for the epithelial\u2010to\u2010mesenchymal transition (EMT) by which colorectal cancer (CRC) cells acquire migratory and metastatic capacities. However, frequent dosing of LY can produce highly toxic metabolites. Alternative strategies to reduce drug side effects can rely on nanoscale drug delivery systems that have led to a medical revolution in the treatment of cancer, improving drug efficacy and lowering drug toxicity. Here, a hybrid nanosystem (DNP\u2010AuNPs\u2010LY@Gel) made of a porous diatomite nanoparticle decorated with plasmonic gold nanoparticles, in which LY is retained by a gelatin shell, is proposed. The multifunctional capability of the nanosystem is demonstrated by investigating the efficient LY delivery, the enhanced EMT reversion in CRCs and the intracellular quantification of drug release with a sub\u2010femtogram resolution by surface\u2010enhanced Raman spectroscopy (SERS). The LY release trigger is the pH sensitivity of the gelatin shell to the CRC acidic microenvironment. The drug release is real\u2010time monitored at single\u2010cell level by analyzing the SERS signals of LY in CRC cells. The higher efficiency of LY delivered by the DNP\u2010AuNPs\u2010LY@Gel complex paves the way to an alternative strategy for lowering drug dosing and consequent side effects.", "headline": "SERS Quantification of Galunisertib Delivery in Colorectal Cancer Cells by Plasmonic-Assisted Diatomite Nanoparticles", "identifier": "https://doi.org/10.1002/smll.202101711", "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", "inLanguage": { "@type": "Language", "alternateName": "eng", "name": "English" }, "keywords": [ "Aurora Universities Network", "Biomaterials", "Biotechnology", "General Materials Science", "General Chemistry" ], "license": "https://creativecommons.org/licenses/by/4.0/", "name": "SERS Quantification of Galunisertib Delivery in Colorectal Cancer Cells by Plasmonic-Assisted Diatomite Nanoparticles", "url": "https://www.openaccessrepository.it/record/78493" }
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