July 24, 2021 Journal article Open Access

Monica Terracciano; Chiara Tramontano; Chiara Tramontano; Gianluigi Zito; Stefano Managò; Luca De Stefano; Enza Lonardo; Donatella Delle Cave; Ilaria Rea; Giovanna Chianese; Anna Chiara De Luca

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    <subfield code="a">Chiara Tramontano</subfield>
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    <subfield code="a">Chiara Tramontano</subfield>
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    <subfield code="a">Stefano Managò</subfield>
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    <subfield code="a">Luca De Stefano</subfield>
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    <subfield code="a">Enza Lonardo</subfield>
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    <subfield code="a">Ilaria Rea</subfield>
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    <subfield code="a">Giovanna Chianese</subfield>
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    <subfield code="a">Anna Chiara De Luca</subfield>
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    <subfield code="a">10.1002/smll.202101711</subfield>
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    <subfield code="a">AbstractThe small molecule Galunisertib (LY2157299, LY) shows multiple anticancer activities blocking the transforming growth factor‐β1 receptor, responsible for the epithelial‐to‐mesenchymal transition (EMT) by which colorectal cancer (CRC) cells acquire migratory and metastatic capacities. However, frequent dosing of LY can produce highly toxic metabolites. Alternative strategies to reduce drug side effects can rely on nanoscale drug delivery systems that have led to a medical revolution in the treatment of cancer, improving drug efficacy and lowering drug toxicity. Here, a hybrid nanosystem (DNP‐AuNPs‐LY@Gel) made of a porous diatomite nanoparticle decorated with plasmonic gold nanoparticles, in which LY is retained by a gelatin shell, is proposed. The multifunctional capability of the nanosystem is demonstrated by investigating the efficient LY delivery, the enhanced EMT reversion in CRCs and the intracellular quantification of drug release with a sub‐femtogram resolution by surface‐enhanced Raman spectroscopy (SERS). The LY release trigger is the pH sensitivity of the gelatin shell to the CRC acidic microenvironment. The drug release is real‐time monitored at single‐cell level by analyzing the SERS signals of LY in CRC cells. The higher efficiency of LY delivered by the DNP‐AuNPs‐LY@Gel complex paves the way to an alternative strategy for lowering drug dosing and consequent side effects.</subfield>
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    <subfield code="a">Biomaterials</subfield>
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    <subfield code="a">Biotechnology</subfield>
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    <subfield code="a">General Materials Science</subfield>
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    <subfield code="a">General Chemistry</subfield>
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    <subfield code="a">Monica Terracciano</subfield>
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  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">SERS Quantification of Galunisertib Delivery in Colorectal Cancer Cells by Plasmonic-Assisted Diatomite Nanoparticles</subfield>
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    <subfield code="c">2021-07-24</subfield>
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